Table 4.
BZs induced seizure related AEs
| Case (n) | No case (n) | Total | % | ROR | 95%CI | |
|---|---|---|---|---|---|---|
| All | 4653 | 883,051 | 887,704 | 0.52 | ||
| Eszopiclone | 4 | 273 | 277 | 1.44 | 2.78 | 1.036–7.469 |
| Zopiclone | 8 | 907 | 915 | 0.87 | 1.68 | 0.835–3.362 |
| Zolpidem | 21 | 2725 | 2746 | 0.76 | 1.46 | 0.952–2.252 |
| Triazolam | 11 | 847 | 858 | 1.28 | 2.47 | 1.361–4.477 |
| Brotizolam | 24 | 1623 | 1647 | 1.46 | 2.82 | 1.880–4.218 |
| Rilmazafone | 0 | 121 | 121 | 0.00 | 0.00 | |
| Lormetazepam | 2 | 155 | 157 | 1.27 | 2.45 | 0.607–9.885 |
| Estazolam | 1 | 360 | 361 | 0.28 | 0.53 | 0.074–3.753 |
| Nitrazepam | 19 | 2479 | 2498 | 0.76 | 1.46 | 0.927–2.289 |
| Flunitrazepam | 13 | 2012 | 2025 | 0.64 | 1.23 | 0.711–2.118 |
| Quazepam | 3 | 240 | 243 | 1.23 | 2.37 | 0.760–7.413 |
| Haloxazolam | 0 | 3 | 3 | 0.00 | 0.00 | |
| Flurazepam | 0 | 22 | 22 | 0.00 | 0.00 | |
| Etizolam | 40 | 2253 | 2293 | 1.74 | 3.39 | 2.476–4.640 |
| Clotiazepam | 19 | 358 | 377 | 5.04 | 10.11 | 6.367–16.051 |
| Flutazolam | 0 | 11 | 11 | 0.00 | 0.00 | |
| Alprazolam | 8 | 635 | 643 | 1.24 | 2.39 | 1.191–4.810 |
| Bromazepam | 10 | 1088 | 1098 | 0.91 | 1.75 | 0.936–3.256 |
| Lorazepam | 4 | 626 | 630 | 0.63 | 1.21 | 0.454–3.243 |
| Diazepam | 13 | 1107 | 1120 | 1.16 | 2.23 | 1.291–3.859 |
| Cloxazolam | 1 | 105 | 106 | 0.94 | 1.81 | 0.252–12.956 |
| Fludiazepam | 4 | 13 | 17 | 23.53 | 58.44 | 19.049–179.308 |
BZs, benzodiazepines; ROR, reporting odds ratio; 95%CI, 95% confidence interval; NA, not available