Multivariate analysis using the JADER database showed a significant increase in ROR for 23 psychotropic drugs, even after adjustment for sex, age, and medical history of BPH and depression. When considering the risk of drug-induced urinary retention, various pharmacologic factors may come into play. In addition to anticholinergic effects, we need to look at sympathomimetic pharmacologic effects and actively check with the patient regarding the presence or absence of urinary retention.