Table 2. IVF outcomes and obstetrics results of the patients compared in between the groups.
|
Variables |
EFS (n=6) |
Non-EFS (n=409) |
p |
|
Duration of stimulation (days) |
10.0±1.3 |
9.1±1.2 |
0.56 |
|
Gonadotrophin dose (IU) |
1858.3±205.9 |
2082.6±420.9 |
0.19 |
|
Antral follicle count |
36.8±8.4 |
39.7±13.1 |
0.59 |
|
# Follicles on the trigger day |
30.5±7.2 |
32.9±12.0 |
0.62 |
|
# Follicles ≥14 mm on the trigger day |
25.2±5.9 |
30.9±11.1 |
0.21 |
|
E2 level on the trigger day (pg/mL) |
5641.8±1293.3 |
5771.8±1756.7 |
0.86 |
|
P4 level on the trigger day (ng/mL) |
0.69±0.13 |
0.77±0.15 |
0.23 |
|
# Oocyte |
13.3±2.7 |
26.2±9.8 |
<0.01* |
|
Oocyte utilization rate (%)a |
62.6±8.4 |
80.4±11.6 |
<0.01* |
|
# MII oocytes |
10.8±2.5 |
22.9±9.7 |
<0.01* |
|
Oocyte maturity index (%)b |
81.1±7.8 |
85.9±10.5 |
0.27 |
|
# 2pn embryos |
9.2±2.0 |
18.7±8.7 |
<0.01* |
|
Cleavage embryos |
6.5±0.5 |
17.4±8.1 |
<0.01* |
|
# Blastocyst |
3.3±0.8 |
5.3±1.4 |
<0.01* |
|
Positive pregnancy test result (n) |
50.0 (3) |
58.4 (239) |
0.49 |
|
Livebirth |
33.3 (2) |
49.4 (202) |
0.69 |
*: Statistically significant
aOocyte utilization rate: For EFS, number of oocytes/follicle on the second egg retrieval after hCG trigger and for non-EFS, number of oocytes/follicle on the first egg retrieval after GnRHa trigger.
bOocyte maturity index: For EFS, #: MII oocytes/oocytes collected on the second egg retrieval after hCG trigger and for non-EFS, #: MII oocytes/oocytes collected on the first egg retrieval after GnRHa trigger.
Mean ± SD and percentage where appropriate
SD: Standard deviation, EFS: Empty follicle syndrome, MII: Metaphase II, GnRHa: Agonists gonadotropin-releasing hormone, hCG: Human chorionic gonadotropin, IVF: In vitro fertilization, E2: Estradiol, P4: Progesterone