TABLE 7.
Histological features relevant for the detection of EUS‐FNAB samples of PDAC. Reproduced from reference. 8
| 1. Overall low power appearance | Necrotic debris in the background |
| Abundant detached atypical cells in the necrotic debris or clot | |
| Numerous sheets of atypical cells | |
| 2. Structural atypia/abnormalities | Irregular contour (ex. cribriform pattern) |
| Lack of uniformity of glandular formation | |
| Luminal necrosis | |
| 3. Cellular atypia | Enlarged nuclei |
| Irregular nuclear contour | |
| Prominent nucleoli | |
| Hyperchromatism | |
| Anisonucleosis 4:1 within a single duct | |
| Morphological heterogeneity of intracellular mucus | |
| Easily identifiable mitotic figures | |
| Clear or foamy cell change in the cytoplasm | |
| 4. Parenchymal invasion | Haphazard (or irregular) arrangement of glands |
| Stromal desmoplasia |