Table 1.
Time point | Normal group (n = 5) |
Model group (n = 5) |
ZYP group (n = 5) |
rhEGF group (n = 5) |
SSD group (n = 5) |
---|---|---|---|---|---|
Before injection of STZ | 6.59±0.35 | 6.78±0.44 | 6.72±0.43 | 6.70±0.48 | 6.64±0.60 |
Day 7 after STZ injection | 6.17±0.40 | 29.72±3.30a | 30.44±2.66a | 28.20±1.78a | 29.78±3.34a |
Day 14 after STZ injection | 6.28±0.23 | 31.94±1.38a | 32.90±0.46a | 30.04±2.86a | 29.30±3.87a |
Day 7 after treatment | 6.21±0.41 | 30.28±3.44a | 27.32±2.70a | 28.40±3.19a | 28.94±3.47a |
Day 14 after treatment | 6.26±0.31 | 30.02±2.62a | 24.68±2.06ab | 27.20±3.16a | 28.78±3.82a |
Notes: Normal group: normal rats with skin ulcer; Model group: non-intervention group after the establishment of diabetic ulcer model; ZYP group: after modelling diabetic ulcer, treatment with ZYP formula; rhEGF group: after modelling diabetic ulcer, treatment with epidermal growth factor; SSD group: after modelling diabetic ulcer, treatment with 1% sulfadiazine silver cream. ZYP: Zuyangping; rhEGF: epidermal growth factor; SSD: 1% sulfadiazine silver cream. aP < 0.05, compared with the normal control group; bP < 0.05, compared with the model group. All the treated groups were compared with the model group using the Dunnett’s test. Student’s t-test was used to compare differences between the normal and model groups.