TABLE 1.
Treatment | Viral yield (PFU, 107)b at:
|
|||
---|---|---|---|---|
18 h | 24 h | 28 h | 32 h | |
DMSO | 6.5 ± 0.3 | 12 ± 1 | 21 ± 1 | 17 ± 1 |
SB203580 | 6.0 ± 0.3 | 8.0 ± 0.4 | 8.9 ± 0.4 | 7.7 ± 0.4 |
Cells (5 × 106) were pretreated with 30 μM SB203580 or DMSO for 1 h and infected with wt HSV-1 in the continuous presence of SB203580 or DMSO.
Viral yields were determined at 18, 24, 28, and 32 h postinfection. Each value represents the mean ± standard deviation from three independent experiments, and in each experiment triplicate determinations were performed.