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. 2024 Nov 25;15:10213. doi: 10.1038/s41467-024-53223-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — The probability of PFS is shown according to HER2 IHC status (panel A) HER2 biomarkers based on exploratory cutoff values (panels B, C, D, F, G), and type of HER2 gene amplification (panel E). ^aExploratory cutoff values (panels B, C, D, F, G) were determined using receiver operating characteristics analysis: H-score cutoff = 240; HER2/CEP17 ratio cutoff = 6.30; HER2 ISH signal cutoff = 11.25; HER2 ApCN cutoff = 30.99; serum HER2ECD cutoff = 23.5 ng/mL. ^bAmplification type (panel E) was reported from Guardant Health. Amp, amplification; ApCN, adjusted plasma copy number; HER2, human epidermal growth factor receptor 2; HER2ECD, human epidermal growth factor receptor 2 extracellular domain; IHC, immunohistochemistry; ISH, in situ hybridization; mPFS, median progression-free survival; NA, not applicable; ND, not determined; PFS, progression-free survival.