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a) “Offloading” is the final step of NRP biosynthesis, wherein the mature NRP is released from the enzymatic assembly line via a thioesterase (TE)-catalyzed nucleophilic attack. Depending on the nature of the nucleophile, this reaction may generate distinct NRP topologies and the five most common types are shown above. b) Cartoon illustration of the five most common NRP topologies and two well-known examples for each category.
