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Structural features, SEC purity and thermodynamic properties of anti-IL-36R×IL-17A BsAbs.
| Anti-IL-36R×IL-17A BsAbs | 700005 | 700007 | 700009 (HB0043) |
|---|---|---|---|
| Length of linker 2 | 15 | 20 | 25 |
| SEC purity(%) | 86.4 | 91.9 | 94.5 |
| Tm value (°C) | 67.8 | 67.7 | 68.3 |
| Tagg value (°C) | 61.6 | 60.7 | 61.8 |
| NCI/ADR-RES IC50 (nM) | 0.5 | 0.5 | 0.7 |
| HT1080 IC50 (nM) | 0.1 | 0.1 | 0.1 |
