Table 2.
Binding affinity of BsAbs and mAbs to the targets from different species.
| Antibody | IL-36R | ka (M-1s-1) | kd (s-1) | KD (nM) |
|---|---|---|---|---|
| HB0043 | Human | 3.91×105 | 3.04×10-4 | 0.78 |
| Cynomolgus | 2.13×105 | 2.56×10-3 | 12.00 | |
| Rabbit | NB | NB | NB | |
| Rat | NB | NB | NB | |
| Mouse | NB | NB | NB | |
| HB0034 | Human | 1.69×106 | 7.06×10-4 | 0.42 |
| Cynomolgus | 4.66×105 | 6.82×10-3 | 14.60 | |
| Rabbit | NB | NB | NB | |
| Rat | NB | NB | NB | |
| Mouse | NB | NB | NB | |
| HB0034SA | Human | NB | NB | NB |
| Rabbit | NB | NB | NB | |
| Rat | 1.05×106 | 1.70×10-4 | 0.16 | |
| Mouse | 7.04×105 | 4.00×10-4 | 0.57 | |
| IL-17A | ka (M-1s-1) | kd (s-1) | KD (nM) | |
| HB0043 | Human | 1.29×107 | 1.41×10-4 | 0.01 |
| Cynomolgus | 4.03×106 | 5.35×10-4 | 0.13 | |
| Rabbit | 9.68×105 | 3.54×10-3 | 3.66 | |
| Rat | 3.63×105 | 1.65×10-3 | 4.54 | |
| Mouse | 1.44×106 | 7.10×10-4 | 0.49 | |
| HB0017 | Human | 1.50×107 | 2.34×10-4 | 0.02 |
| Cynomolgus | 4.87×106 | 5.14×10-4 | 0.11 | |
| Rabbit | 2.25×106 | 8.51×10-3 | 3.78 | |
| Rat | 1.66×105 | 1.25×10-3 | 7.50 | |
| Mouse | 5.37×106 | 1.03×10-3 | 0.19 |
NB, No Binding.