Table 4.

Single-dose pharmacokinetic study in cynomolgus monkeys.

	HB0017	HB0034	HB0043
Animal species	Cynomolgus monkey	Cynomolgus monkey	Cynomolgus monkey
Administration	s.c.	i.v.	i.v.
Dosage cycle (mg/kg)	3, 10, 30	5, 15, 50	3, 10, 30
AUC(0~t) (h*mg/mL)	18.8 ( ± 2.1) ~191.4 ( ± 37.9)	14.5 ( ± 2.4) ~159.4 ( ± 32.6)	13.2 ( ± 3.3) ~169.6 ( ± 39.6)
Cmax (μg/mL)	48.1 ( ± 6.6) ~522.7 ( ± 55.1)	158.0 ( ± 17.9) ~1579.3 ( ± 332.7)	99.9 ( ± 13.6) ~1143.7 ( ± 173.5)
t1/2 (h)	149.7 ( ± 99.7) ~268.8 ( ± 31.2)	124.8 ( ± 48.0) ~160.8 ( ± 45.6)	138.9 ( ± 58.0) ~170.4 ( ± 53.0)
ADA detection rate	0~33.3%	0~67%	83.8%~100%