Summary of findings 2. Time to death.

Estimate of effects, confidence intervals, and certainty of the evidence for time to death in paediatric patients undergoing surgery for congenital heart disease
Population: paediatric patients undergoing surgery for congenital heart disease Interventions: levosimendan Comparator (reference): placebo Outcome: time to death Setting: inpatient			Figure 2
Total studies: 1 Total participants: 187 Total events: 7	Relative effect (95% CI)	No. of participants (studies)	Comments
Levosimendan	HR 0.74 (0.16 to 3.28)	94 (1 RCT)	Levosimendan likely results in a reduction of momentary probability of death compared to placebo
Placebo	HR 1	93 (1 RCT)	‐

GRADE Working Group grades of evidence (or certainty in the evidence)

High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.

Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.

Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect.

Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect.

Abbreviation(s)
CI: confidence interval; HR: hazard ratio; No.: number; RCT: randomised controlled trial.