Fig. 6.

Induction of the InSETG-4 expression in response to DNA damage. A A time course of etoposide induction of InSETG-4 relative to DMSO-treated K562 cells. B Left and middle: expression levels of InSETG-4 normalized to HeLa cells after 24 h of exposure to DMSO control (left) or etoposide (middle) across different cell lines. Right: induction of InSETG-4 after 24 h of exposure to etoposide relative to the DMSO controls. C Induction of InSETG-4 by 1 mM methyl methanesulfonate (MMS) or 1.5 mM hydrogen peroxide (H₂O₂) for 24 h using DMSO or H₂O as the controls, respectively, in K562 cell line. D Time course of InSETG-4 induction by 50 Gy X-ray irradiation in K562 cell line relative to untreated cells. E Effect of ATM, ATR, and DNA-PKcs inhibitors on the InSETG-4 induction by etoposide. Error bars represent SD. Asterisks denote significant differences (*p < 0.05, two-sided homoscedastic t-test)