FIGURE 5.

Evasion by staphylococcal toxins. Various leukocidins bind specific GPCRs, after which they form a pore and lyse host cells. PSMs are released inside the phagosome and can bind via FPR2. SAgs cross-link major histocompatibility complex class II and T-cell receptors. Abbreviations: GPCR, G-protein-coupled receptor; FPR, formyl protein receptor; PSMs, phenol-soluble modulins; Hla, hemolysin-alpha; SAgs, superantigens; MHC II, major histocompatibility complex II; TCR, T-cell receptor. The figure was adapted from Servier Medical Art.