Table 1.

Genes significantly repressed by OSM, TGF-β1, SNAI1, and ZEB1

Gene (Average Log2Fold Change)	Vec vs OSM		Vec vs TGF-β1		Vec vs SNAI1		Vec vs ZEB1		Interferon-Stimulated Gene
	Log2Fold Change	padj	Log2Fold Change	padj	Log2Fold Change	padj	Log2Fold Change	padj
GBP1 (− 3.7825)	− 2.85	5.13E–102	− 2.40	1.60E–66	− 8.42	1.99E–217	− 1.46	5.36E–21	Yes [26, 60–62]
OAS3 (− 3.5425)	− 4.68	1.10E–24	− 1.60	1.89E–05	− 6.96	4.45E–107	− 0.93	1.51E–06	Yes [26, 60, 62, 63]
GBP2 (− 3.4050)	− 1.27	3.31E–16	− 4.87	3.99E–142	− 6.48	2.30E–143	− 1.00	8.85E–10	Yes [60, 62]
IFI6 (− 3.3350)	− 4.27	7.18E–170	− 1.49	1.34E–25	− 5.83	3.73E–237	− 1.75	1.95E–27	Yes [26, 60–62]
IFI27 (− 3.1125)	− 4.72	6.93E–18	− 2.32	1.15E–13	− 4.41	4.07E–31	− 1.45	1.48E–13	Yes [60–62]
CCL5 (− 2.9575)	− 3.31	3.27E–12	− 1.42	8.61E-11	− 5.57	1.70E–73	− 1.53	2.03E–17	Yes [60, 61]
IFIH1 (− 2.8875)	− 1.69	8.58E–14	− 1.74	1.88E–13	− 6.19	4.19E–76	− 1.93	1.09E–24	Yes [26, 60–62, 64]
SLC15A3 (− 2.7850)	− 3.31	7.44E–27	− 1.71	5.20E–09	− 4.74	4.55E–44	− 1.38	2.02E–12	Yes [26, 60, 62]
DSP (− 2.6275)	− 3.79	3.30E–105	− 1.82	2.18E–29	− 2.36	2.37E–66	− 2.54	1.02E–55	No
CDH3 (− 2.5625)	− 3.35	1.87E–15	− 2.24	4.21E–37	− 3.11	2.95E–68	− 1.55	1.57E–19	No
GBP4 (− 2.5075)	− 3.11	9.10E–23	− 2.29	4.27E–16	− 3.34	6.15E–14	− 1.29	1.38E–10	Yes [60]
L1CAM (− 2.4950)	− 3.54	8.17E–45	− 1.11	1.61E–08	− 3.42	4.82E–50	− 1.91	2.83E–26	No
PARP14 (− 2.4425)	− 1.52	2.88E–18	− 1.87	2.59E–26	− 5.04	2.47E–52	− 1.34	2.60E–13	Yes [64]
S100A8 (− 2.3775)	− 2.10	2.69E–07	− 2.72	7.29E–15	− 3.69	7.08E–19	− 1.00	1.26E–06	Yes [60]
HERC6 (− 2.3325)	− 2.15	5.33E–19	− 1.43	6.45E–09	− 4.07	4.68E–21	− 1.68	1.86E–19	Yes [26, 60, 64]
MX1 (− 2.3250)	− 3.35	7.14E–12	− 1.07	9.28E–03	− 4.16	8.19E–22	− 0.72	3.08E–04	Yes [26, 60–64]
OAS2 (− 2.3000)	− 3.75	4.88E–13	− 1.43	1.74E–04	− 3.33	1.30E–13	− 0.69	3.31E–04	Yes [26, 60–63]
IFITM1 (− 2.2900)	− 1.60	3.12E–03	− 2.51	3.92E–13	− 4.44	2.00E–26	− 0.61	1.10E–02	Yes [26, 60–63]
SAMD9 (− 2.2775)	− 1.26	1.39E–08	− 2.07	1.93E–20	− 4.34	2.83E–63	− 1.44	1.20E–14	Yes [60]
GBP3 (− 2.1675)	− 2.20	2.20E–10	− 1.25	7.88E–05	− 4.29	9.72E–28	− 0.93	2.30E–05	Yes [60]
TRANK1 (− 2.1000)	− 2.31	5.76E–08	− 1.38	1.19E–04	− 3.83	6.08E–20	− 0.88	5.10E–05	Yes [60]
CFB (− 2.0825)	− 4.20	1.32E–38	− 2.01	2.82E–13	− 1.48	3.29E–08	− 0.64	1.72E–02	Yes [60]
EPSTI1 (− 2.0525)	− 1.91	3.92E–28	− 2.14	1.52E–33	− 2.72	9.62E–51	− 1.44	1.89E–17	Yes [26, 60]
PARP10 (− 2.0375)	− 2.58	8.92E–26	− 1.54	3.02E–12	− 2.97	1.29E–37	− 1.06	2.57E–07	Yes [60]
MUC1 (− 2.0125)	− 1.75	1.23E–08	− 2.50	1.43E–96	− 2.63	5.32E–78	− 1.17	4.56E–14	No
KRT81 (− 1.9750)	− 3.20	9.84E–32	− 0.60	1.85E–02	− 3.06	8.56E–32	− 1.04	1.14E–07	No
DDX60 (− 1.9000)	− 1.16	1.28E–10	− 1.15	3.81E–10	− 4.20	7.51E–74	− 1.09	6.03E–10	Yes [26, 60, 62]
APOL1 (− 1.8450)	− 2.20	7.13E–07	− 1.41	1.90E–04	− 3.05	4.85E–13	− 0.72	2.01E–03	Yes [60, 64]
DSC2 (− 1.8400)	− 0.91	2.31E–02	− 1.82	2.21E–07	− 3.84	1.01E–19	− 0.79	6.49E–04	No
PKP3 (− 1.8275)	− 2.00	1.67E–13	− 1.18	4.44E–06	− 3.36	2.16E–31	− 0.77	5.28E–04	No
USP18 (− 1.8275)	− 2.07	2.67E–11	− 1.31	1.51E–05	− 2.70	1.70E–09	− 1.23	1.69E–09	Yes [60, 61, 64]
PODXL (− 1.7875)	− 1.00	5.08E–05	− 2.19	6.14E–06	− 3.02	9.91E–33	− 0.94	2.52E–19	No
RSAD2 (− 1.7825)	− 1.53	3.66E–03	− 1.17	2.84E–03	− 2.85	3.92E–10	− 1.58	5.36E–16	Yes [26, 61–64]
PTGIS (− 1.7550)	− 1.97	1.19E–05	− 1.47	2.87E–10	− 2.08	9.05E–19	− 1.50	3.62E–15	No
KIF21A (− 1.7150)	− 1.98	1.65E–14	− 0.97	8.51E–05	− 3.08	1.25E–29	− 0.83	3.11E–04	No
DHX58 (− 1.7125)	− 1.46	1.32E–05	− 0.88	7.91E–03	− 3.71	2.38E–23	− 0.80	5.97E–04	Yes [60, 64]
UBE2L6 (− 1.6725)	− 1.19	1.04E–08	− 1.77	4.29E–17	− 3.13	4.30E–45	− 0.60	1.62E–02	Yes [60, 64]
HPSE (− 1.6375)	− 2.31	1.06E–70	− 1.32	4.04E–20	− 2.30	1.09E–85	− 0.62	2.58E–04	Yes [60, 62]
SP140L (− 1.6175)	− 2.36	5.04E–12	− 1.26	4.08E–05	− 1.91	5.13E–05	− 0.94	1.86E–05	No
ITPR3 (− 1.5775)	− 1.67	1.69E–06	− 0.97	3.75E–03	− 2.65	5.34E–14	− 1.02	1.67E–06	No
SAMHD1 (− 1.5300)	− 1.43	8.29E–25	− 0.86	1.02E–08	− 3.12	5.38E–95	− 0.71	9.84E–05	Yes [60, 63]
MAP3K1 (− 1.4750)	− 1.69	1.26E–28	− 2.03	1.18E–40	− 0.77	7.36E–08	− 1.41	1.71E–19	No
LY6E (− 1.4550)	− 1.68	1.34E–10	− 1.35	5.82E–07	− 1.58	2.34E–09	− 1.21	4.56E–14	Yes [60, 65]
PSMB9 (− 1.4425)	− 0.60	2.61E–03	− 1.44	3.01E–12	− 2.71	3.17E–09	− 1.02	8.11E–08	Yes [60, 64]
TMEM108 (− 1.4250)	− 0.70	1.75E–04	− 0.79	2.62E–05	− 3.47	1.40E–59	− 0.74	3.76E–04	No
ISG20 (− 1.2825)	− 1.19	3.93E–03	− 1.09	2.88E–03	− 2.24	4.72E–09	− 0.61	2.58E–02	Yes [26, 60, 61, 64, 65]
CXCL16 (− 1.2500)	− 1.14	3.13E–04	− 0.76	1.84E–02	− 2.13	3.72E–11	− 0.97	7.50E–06	Yes [66]
DDX60L (− 1.2375)	− 1.12	7.11E–07	− 0.92	6.18E–05	− 2.21	6.81E–22	− 0.70	1.74E–03	Yes [26]
IFIT5 (− 0.9500)	− 1.23	2.95E–03	− 0.92	2.25E–02	− 0.82	4.50E–02	− 0.83	1.43E–04	Yes [60, 62, 63]
MDN1 (− 0.9425)	− 0.81	3.11E–09	− 0.91	4.72E–10	− 1.11	8.79E–15	− 0.94	6.63E− 07	No

Of 73 significantly differentially regulated genes compared to Vec cells, 50 are consistently repressed by each of these EMT-inducing factors and are listed above. Adjusted p values (padj) denote significance