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. 2024 Nov 26;26:163. doi: 10.1186/s13058-024-01919-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Low-dose tamoxifen treatment reduces the amount of thick and densely organised collagen in the breast. A–D Change in area of A total birefringence (all organised collagen), B thin collagen fibres, C intermediate collagen fibres, or D thick collagen fibres by merged treatment arms of tamoxifen or placebo. Percentages are relative to the total biopsy area, and all analyses were adjusted for menopausal status. P_-trend for linear trends across all groups. *P < 0.05 and ***P < 0.001 between indicated groups