Table 5.
Reports of dual therapy with Amoxicillin and VPZ in the treatment of H. Pylori infection
| Authors (year) |
Country | Number | Dose of VPZ | Dose of amoxicillin | Duration of treatment |
Eradication rates (ITT) | Adverse events |
|---|---|---|---|---|---|---|---|
| Gotoda T et al. (2020) [14] | Japan | 60 | 20 mg, bid | 750 mg, bid | 7 days | 85.0% |
10% (6/60) |
| Furuta T et al. (2020) [22] | Japan | 56 | 20 mg, bid | 500 mg, tid | 7 days | 92.9% |
16.0% (9/56) |
| Suzuki S et al. (2020) [15] | Japan | 168 | 20 mg, bid | 750 mg, bid | 7 days | 84.5% | 27.4% (46/168) |
| Horii T et al. (2021) [23] | Japan | 19 | 20 mg, bid | 750 mg, bid | 7 days | 84.2% |
36.8% (7/19) |
| Zuberi BF et al. (2022) [24] | Pakistan | 96 | 20 mg, bid | 1000 mg, bid | 14 days | 93.5% |
12.5% (12/96) |
| Chey WD et al. (2022) [25] | US and Europe | 348 | 20 mg, bid | 1000 mg, tid | 14 days | 78.5% | 29.9% (104/348) |
| Hu Y et al. (2022) [16] | China | 37 | 20 mg, bid | 1000 mg, bid | 10 days | 89.2% | 29.7% (11/37) |
| 37 | 20 mg, bid | 1000 mg, tid | 10 days | 81.1% |
24.3% (9/37) |
||
| 24 | 20 mg, bid | 1000 mg, bid | 7 days | 66.7% |
16.7% (4/24) |
||
| 21 | 20 mg, bid | 1000 mg, tid | 7 days | 86.0% |
23.8% (5/21) |
||
| Lin Y et al. (2022) [17] | China | 85 | 20 mg, bid | 750 mg, qid | 7 days | 63.5% |
16.9% (14/85) |
| 84 | 20 mg, bid | 500 mg, qid | 7 days | 58.3% |
13.2% (11/84) |
Abbreviations: ITT, intention-to-treat; VPZ, vonoprazan; bid, twice daily; tid, three times daily; qid, four times daily