Table 2.
Univariate and Multivariate Analysis for Overall Survival, the 120 hCC Patients in Our Center
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Overall Survival | Overall Survival | ||||
| p value | p value | HR | 95.0% CI | ||
| Lower | Upper | ||||
| Age, ≥60y vs <60y | 0.183 | NA | NA | NA | NA |
| Sex, Female vs Male | 0.875 | NA | NA | NA | NA |
| Tumor size, DM, <4cm vs ≥4cm | 0.89 | 0.934 | 1.033 | 0.482 | 2.211 |
| AFP, >20ng/mL vs ≤20ng/mL | 0.577 | 0.213 | 1.628 | 0.756 | 3.506 |
| Multiple tumors (≥2), Yes vs No | 0.177 | 0.131 | 1.878 | 0.829 | 4.254 |
| MVI, Yes=1 vs No | <0.001 | 0.005 | 3.598 | 1.474 | 8.787 |
| Pathological stage, I vs II–IV | 0.014 | NA | NA | NA | NA |
| Cirrhosis, Yes vs No | 0.23 | 0.002 | 5.284 | 1.826 | 15.289 |
| BCLC stage, B vs A | <0.001 | 0.084 | 2.466 | 0.887 | 6.858 |
| Viral hepatitis, No vs Yes | 0.789 | NA | NA | NA | NA |
| LN metastasis, Yes vs No | 0.219 | 0.833 | 1.127 | 0.372 | 3.415 |
| ALT, >80U/L vs ≤80U/L | 0.208 | NA | NA | NA | NA |
| Total bilirubin, >1.0mg/dL (17.1μmol/L) vs ≤1.0mg/dL (17.1μmol/L) | 0.929 | NA | NA | NA | NA |
| Albumin, <35g/L vs ≥35g/L | 0.719 | NA | NA | NA | NA |
| Child Pugh, B vs A | NA | NA | NA | NA | NA |
| TACE, Yes vs No | 0.191 | 0.195 | 0.626 | 0.308 | 1.272 |
| Ku80, high vs low | 0.003 | 0.041 | 2.325 | 1.035 | 5.221 |
| Ku70, high vs low | 0.002 | 0.035 | 2.328 | 1.062 | 5.101 |
| CD8, high vs low | 0.023 | 0.007 | 0.355 | 0.168 | 0.749 |