Table 3. Characteristics of patients presenting with acidosis or developing acidosis during follow-up.
|
HNF4A-MODY n=2 |
HNF1A-MODY n=2 |
HNF1B-MODY n=1 |
NEUROD1-MODY n=1 |
INS-MODY n=1 |
|||
|
Sex |
M |
M |
M |
F |
M |
F |
F |
|
Age of diagnosis, years |
8.2 |
10 |
12 |
15 |
15 |
18 |
16.6 |
|
GAD |
Negative |
Negative |
Negative |
Negative |
Negative |
Negative |
Negative |
|
ICA |
No data |
Negative |
Negative |
Positive |
Negative |
Negative |
Negative |
|
Anti insulin |
Negative |
Negative |
Negative |
Negative |
Negative |
Negative |
Negative |
|
Family history |
No |
No |
Yes (grandfather) |
Yes (brother, grandmother, grandfather) |
Yes (father) |
Yes (father uncle, aunt) |
Yes Father |
|
Glucose at Dx (mg/dL) |
674 |
548 |
443 |
210 |
600 |
281 |
269 |
|
C-peptide (ng/mL) |
0.60 |
0.53 |
0.1 |
0.1 |
0.1 |
0.1 |
3.47 |
|
HbA1c (%) |
11.78 |
10.6 |
13.2 |
9 |
8 |
7.5 |
11.2 |
|
Treatment |
Int insulin the same treatment continued |
Int insulin after diet |
Int insulin the same treatment continued |
Int insulin the same treatment continued |
Int insulin the same treatment continued |
Int insulin the same treatment continued |
Int insulin the same treatment continued |
F: female, M: male, HbA1c: glycated hemoglobin, int: initially, MODY: maturity onset diabetes of the young