Figure 8.

Effect of Effect of coriander oil and metformin on pancreatic anti-apoptotic marker, BCL2 in dexamethasone-induced insulin resistance in rats (RI). Photomicrograph of a pancreatic sections (A) control group displaying most of the islet cells are BCL2 positive cells; (B) IR group displaying few of the islet cells are BCL2 positive cells; (C) metformin group (50 mg/kg/day, PO) displaying many of the islet cells are BCL2 positive cells; (D) coriander oil group (low dose, (CO 0.5 mL/kg, PO)) displaying some of the islet cells are BCL2 positive cells; (E) coriander oil group (high dose, (CO 1 mL/kg, PO)) displaying many of the islet cells are BCL2 positive cells (Avidine biotin peroxidase stain with Hx counter stain ×400, scale bar = 50 µm); (F) Bar graph showing the difference in number of immunopositive BCL2 cells in islets of Langerhans per field in all studied groups that were quantified at ×400. Results were analyzed by one-way ANOVA followed by the post-hoc Tukey test. Results are shown in mean ± SEM (n = 6). *^{, @, $} p < 0.05 compared to normal, IR, and high dose coriander oil (CO 1) groups, respectively.