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. 2024 Nov 8;13(11):1369. doi: 10.3390/antiox13111369

Table 1.

General characteristics of the studies in animals and results: summary of the main characteristics of the included studies and presentation of the results of the studies, including the effects of the interventions on oxidative stress biomarkers.

Author Compound Antioxidant Action
↓RONS ↓ RONS Synthesis ↓ RONS Damage Improved Antioxidant Defense
NO RONS iNOS COX2
LPO
NOX
MPO NF-κB/
Iκ-Bα
MDA
LP
PTN DNA SOD CAT GPx GR
GSH
GST
Nrf2 TAC/
TAS
Hormones
[26] Melatonin X
[27] Dehydroepiandrosterone (DHEA) X
[28] Obestatin X X X X X
Synthetic compounds
[29] GL-V9
synthetic flavonoid
X X X X X X
[30] Glucose-lysine MRPs X X X X X X X X
[31] ZnO nanoparticles (ZnONP) and ZnO microparticles (ZnOMP) X X X X
[32] Chromium-D-phenylalanine complex
(Cr(D-phe)
X X X
[33] Hydrogen-rich water (HRW) X X X
[34] P-chloro-phenylselene cholesterol (PCS) X X X
[35] Selenium nanoparticles (ULP-SeNPs) X X X X X X
[36] Hydroxyproline X X X X X X X
[37] LL202 (synthetic flavonoid) X X X X
[38] RSV imine (IRA), 2-methoxyl-3,6-dihydroxyl-IRA 3,4,5,4-tetramethoxystilbene (C33) X
[39] FA-97 (synthetic phenolic compound) X X X X
[40] Unconjugated bilirubin (UCB) X X
[41] Taurine-loaded chitosan pectin nanoparticles (Tau-CS-PT-nps) and chitosan pectin nanoparticles (CS-PT-nps) X X
[42] Turmeric-derived nanoparticles X
[43] (R,R)-BD-AcAc2 X X X X X
[44] Lawesson’s reagent X X
[45] Nano-selenium modified with Eucommia ulmoides polysaccharide X X X X X X X
[46] Galactosylated polymeric nanocargoes X X X X X X
[47] Edible nanoparticles similar to exosomes from Portulaca oleracea L. X
[48] Ferulic acid X X X X
[49] Ferulic acid X X X X X X X
[50] Res-CDF
(cross-linked organic cyclodextrin-metal structure encapsulating resveratrol)
X X X X X X
[51] Lipoic acid and/or N-acetylcysteine X X X X
Chemical products derived from sources other than plants
[52] Phycocyanin X X X X
[53] Lycopene X X X X X X
[54] Melitin X X X X
[55] Shrimp peptide (SP) X X
[56] Polysaccharopeptide from sanghuang mushroom X
[57] Inosine X X X X X X X X
[58] Sodium butyrate X X X
[59] Sea conch peptides hydrolysate X
[60] Astaxanthin X X X
[61] Astaxanthin X X
Polyphenols and other natural active compounds from medicinal plants
[62] P. argentea methanolic extract (PAME) X X X
[63] Pfaffia paniculata extract (Brazilian ginseng) X
[64] American ginseng X
[65] Panaxynol (bioactive component of American ginseng) X X X
[66] Phyllanthus niruri L. spray-dried extract X
[67] Turmeric X X
[68] Grape pomace extract X X X
[69] Grape seed proanthocyanidin extract X
[70] Grape seed proanthocyanidin extract X X X
[71] Isoliquiritigenin X X
[72] Isoquercitrin X X
[73] Quercitrin X
[74] Apple peel polyphenols (dried apple peel) X X X X X
[75] Concentrated apple extract (CAE) X X X
[76] Luteolin X X X X X
[77] Luteolin X X X
[78] Fisetin X X X X X
[79] Myrtus communis hydroalcoholic extract or essential oil X
[80] Myrtus communis subspecies communis extract X X X X
[81] Epicatechin X X X X X X
[82] Methyl gallate X X
[83] Ethanolic extract (etohe) and hexane phase (hexp) from the leaves of Combretum duarteanum (Cd) X X X
[84] Carvacrol (5-isopropyl-2-methylphenol) X X X X X
[85] Tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae) X X X X X
[86] Rosmarinic acid X X X
[87] P-Cymene (p-C) and rosmarinic acid (RA) X X X X X X X
[88] Rosmarinic acid-loaded nanovesicles X X
[89] Moringa seed extract (Moringa oleiferalam) X X X X X
[90] Phoenix loureiroi Kunth methanolic extracts X X X X
[91] Pongamia pinnata (Karanja) X X X X X X
[92] Averrhoa bilimbi L. extract X X X X X
[93] Olea europaea leaf extract X X
[94] Morusin X X
[95] Soy isoflavones X X X X
[96] Geniposide X X X X
[97] Geniposide X X
[98] Geniposide X X X X
[99] Hyperoside (hyp) X X X X
[100] Ocimum gratissimum leaves polyphenol-rich extract X X X X X X
[101] Ocimum gratissimum Linn. X X
[102] Sesbania grandiflora X X X X X
[103] Oligonol X X X X
[104] Thymol X X
[105] Thymol X X X X
[106] Brazilian Berry (Myrciaria jaboticaba) peel aqueous extract X X X X X X
[107] Epigallocatechin gallate (EGCG) X
[108] (-)-Epigallocatechin-3-gallate X
[109] Epigallocatechin gallate (EGCG) X
[110] Carum copticum L. Extract X X
[111] Hesperidin X X X
[112] Hesperidin (HMC) X X X
[113] Hesperidin X X X
[114] Mother tincture (MT) from fresh, young, nonwoody Thuja occidentalis L. X
[115] Phloretin X
[116] Phloretin X X
[117] Curcumin-galactomannoside X X X X X X
[118] Curcumin X
[119] Curcumin in hydroxyethyl starch microspheres X
[120] Curcumin X
[121] Honey polyphenols X X X X X X
[122] Glochidion ellipticum Wight extracts X X X X X
[123] Galangin X X
[124] Galangin X
[125] Taxifolin X X
[126] Flos lonicerae X X X X
[127] Oroxindin X
[128] Polyphenolic maqui extract (Aristotelia chilensis) X X X
[129] Polyphenolic maqui extract (Aristotelia chilensis) X
[130] Acacetin X X
[131] Flavonoid composition rich P. Subpeltata Ortega X X X X X
[132] Juglone (JUG) X X X X
[133] Hydroxytyrosol (HYT) from olive leaves extract (OLE) X X X X
[134] Lingonberry (LB) X X X
[135] Caragana sinica extract X X X X
[136] Quercus brantii (QB) extract X X
[137] T. Occidentalis leaf extract (ato) X X X X X X
[138] Dilodendron bipinnatum Radlk. extract X X X
[139] Copaifera malmei leaf infusion extract (iecm) X X X
[140] Kaempferol (kae) X
[141] 6-Paradol from seeds of Aframomum melegueta X X X
[142] Maesa lanceolata hydroethanolic extract X X X
[143] Garcinia mangostana and α-mangostin extract X X X X X
[144] Garcinia pedunculata bark (AEGP) aqueous extract X X X X
[145] Troxerutin X X X X X X
[146] P. Lentiscus leaf aqueous extract X X X
[147] Wogonin X X X X X
[148] Plant polyphenols (gallic acid, proanthocyanidin, ellagic acid, and tannic acid) X
[149] Gallic acid X X X X
[150] Gallic acid X
[151] Gallic acid X
[152] Arum maculatum X
[153] Coumaric acid and syringic acid X
[154] Syringic acid X X
[155] Syringic acid X X X
[156] Apigenin X X X X
[157] Safranal X
[158] Resveratrol X
[159] Resveratrol in polysaccharide-zein nanoparticles from Mesona chinensis X
[160] Oxiresveratrol (OXY) X X X
[161] Ligustroside X
[162] Isoimperatorin X X
[163] Forsythia suspensa polyphenols X
[164] m Callicarpa nudiflora Hook flavonoids X
[165] Calliandra haematocephala extracts X X X
[166] Diosmin X X X X X
[167] Ziziphus jujuba Mill polyphenol extracts X X X
[168] Geraniol X X X X X X
[169] Terminalia catappa Linn X X X
[170] L. Dentata or L. Stoechas X X X X
[171] Demethyleneberberine—DMB
(component from Cortex Phellodendri Chinensis)
X X
[172] Raphanus sativus L. seeds aqueous extract X X X X
[173] Myrrh X X X
[174] Gegen qinlian X
[175] Ursolic acid X X X X
[176] Lion’s Mane Medicinal Mushroom and Hericium erinaceus (Agaricomycetes) ethanol extract X X X
[177] Polysaccharide from cultured mycelium of Hericium erinaceus X X
[178] Polysaccharides from the edible mushroom Hericium erinaceus X X X
[179] Amphipterygium adstringens extract X X
[180] Mangiferin X X X X X
[181] Portulaca oleracea L. X X X X
[182] Portulaca oleracea L. X X X X X
[183] Andrographolide X X X
[184] Carpolobia lutea G. Don (Polygalaceae) X X X
[185] Lagerstroemia speciosa X X X
[186] Atractylodes macrocephala and Taraxacum herba extracts X X X
[187] Aronia berry X X
[188] Aronia berry extract X
[189] Aronia melanocarpa (Michx.) Elliott. X X X X X
[190] Decursin and decursinol X
[191] Perilla frutescens extract (PE) X X
[192] Glyceollins from daidzein in soybean X X X X X
[193] Catalpol X X X
[194] D-limonene X X X X X
[195] Liriodendrin X X X X X
[196] Yuzu (Citrus junos Tanaka) X
[197] Veronica polita X X X X X
[198] Ziziphus spina-christi fruit extract X X X X X X X X X
[199] Red raspberries X X
[200] Plumieride X X X X
[201] Ipomoea asarifolia aqueous extract X X X X X
[202] Osthole X X X X X X
[203] Polygonum cuspidatum Siebold & Zucc root Extract X X X X X X
[204] Alpinia officinarum X X X X X X X
[205] Magnolol X X
[206] Magnolol contained in a butyrate-derived polymer nanoplatform X
[207] Trichilia catigua ethyl-acetate fraction X
[208] 4-methylesculetin X X
[209] 4-methylesculetin X X
[210] Fargesin X X X X
[211] Sinomenine X X X
[212] Sinomenine X X X X X X X X X X
[213] Stevioside X X X X X X X
[214] Sesamin X X X
[215] Terminalia arjuna hydroalcoholic extract X X X X X
[216] Persea americana Mill. Avocado extract X X X X
[217] Quercetin aglycone X X X X X
[218] 2-O-β-d-Glucopyranosyl-l-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium Barbarum L. X X
[219] Apocynin X X X
[220] Apocynin X X X X X
[221] Crocin X X X
[222] Crocin X X
[223] Crocina X X
[224] Salidroside (salt) X X X
[225] Freeze-dried fruit powder of Actinidia arguta X X X
[226] Tagetes erecta L. flowers hydroalcoholic extract X X X X
[227] Daidzein X X
[228] Ajuga chamaepitys (L.) Schreber subsp. Chia (Schreber) X
[229] Sorbus domestica X X X X X X
[230] Bryophyllum pinnatum (Lamarck) leaf extract X X X X X
[231] Piper umbellatum L. (Piperaceae) X X X X X X
[232] Myristicin X X X X X
[233] Bruguiera gymnorrhiza leaves X X X X
[234] Arjunarishta X X X X X
[235] Antrocaryon micraster X X X
[236] Piperine X X X X X
[237] Puerarin X X X X X X X X X
[238] Rumex japonicus Houtt. X
[239] Gloeostereum incarnatum X X X X X
[240] Sinapic acid X X X X X
[241] Nerolidol X X X X X X
[242] Nerolidol (NRD) X X X X X
[243] Jasonia glutinosa (L.) DC. extract X X X X
[244] Sanhuang shu’ai X X X
[245] Flammuliana velutipes polysaccharide X X X X
[246] of the Syringa oblata Lindl Iridoid glycosides X X
[247] Mucilage Garden cress X
[248] Otostegia fruticosa leaves crude extract X X
[249] Dracocephalum kotschyi methanol extract X X X
[250] Fruit of Rosa odorata doce var.gigantea X X X X X
[251] Artemisia argyi extract X X X X
[252] Inula viscosa ethanolic extract X X X X X
[253] Cepharanthine X X X X
[254] Saposhnikovia divaricata X X
[255] Trigonellafoenum-graecum L. seeds aqueous extract X X X X
[256] Quinic acid X X X X X X X
[257] Echinacea purpurea extract X
[258] Echinacea purpurea polysaccharide X X X X
[259] Daphnetin X X
[260] Oxyberberin X X X X X
[261] Curculigoside (CUR), from Curculigo orchioides Gaertn X X X X X X
[262] Scrophularia striata Boiss aqueous and hydroalcoholic Extracts X X
[263] Picralima nitida seeds crude alkaloidal extract X X X X
[264] Mesua assamica (King&Prain) kosterm. Bark ethanolic extract X X X X X X X
[265] Higenamine X X
[266] Carboxymethyl Poria Polysaccharides X X
[267] 1,8-cineol (eucaliptol) X X X X X X X
[268] Polygonatum Cyrtonema Hua Oligosaccharides X X X X
[269] Polysaccharide from the fermented mycelium of Inonotus obliquus X X X X
[270] Pinus eldarica aqueous and hydroalcoholic extracts X X
[271] Terminalia chebula ethyl acetate extract X X X X X
[272] Ecklonia cava extract X X
[273] Salvia verbenaca extract X X X
[274] Commiphora leptophloeos extract X X X X
[275] Sagittaria sagittifolia L. polysaccharides X X X X
[276] Tetrastigma hemsleyanum root extract X X
[277] Gilaburu (Viburnum opulus L.) fruit extract X X X X
[278] Acidic polysaccharide from Selaginella uncinata (Desv.) Spring X X X X
[279] Lizhong decoction X X X X X
[280] (-)-Syringaresinol X
[281] Aegeline X X X X
[282] Fraxetin X X X X
[283] Honeysuckle X X
[284] Passiflora edulis X
[285] Jinxiang garlic (Allium sativum L.) X
[286] Cinnamaldehyde and hesperetin X X X X X
[287] Anacardium occidentale L. X X X X
[288] Loganic acid X X X X X X
[289] Four sanshools of Zanthoxylum fruit X X X X X
[290] Sea buckthorn X X X X X X
Functional foods and nutrients
[291] Oat β-glucan X X
[292] Blueberry X X X X X X
[293] Riboflavin X X X
[294] Goat whey X X
[295] Garlic oil X X X X
[296] Red bean X X X
[297] Lecithin X X X
[298] Coenzyme Q10 X X X X
[299] Coenzyme Q10 X X X X X
[300] Honey X X X
[301] Flaxseed extract X X X X X X X X
[302] Β-glucans from Lentinus edodes X X X X
[303] Selenium X X
[304] Selenocysteine and selenocystine X X X
[305] Selenium in biogenic nanoparticles X X X X
[306] Camellia oil X X X
[307] Walnut extract X X
[308] Aqueous cinnamon extract X X X X
[309] Cinnamon (Cinnamomum japonicum) subcritical water extract X
[310] Tocotrienol (alpha-tocopherol) X X X X X
[311] Omega 3 X X X X
[312] Eicosapentaenoic acid (EPA) X X X X X
[313] Noni juice-fortified yogurt X X
[314] Isolated from fish skin gelatin hydrolysate
(fsghf3)
X X X X X X
[315] Mannoglucan
(Chinese yam.)
X
[316] Alpha-tocopherylquinone X
[317] Β-carotene X
[318] Momordica charantia X X X X
[319] Virgin coconut oil X X
[320] Pumpkin polysaccharides X
[321] Fermented yogurt X
Probiotics
[322] NTU 101; L. rhamnosus BCRC 16000; L. paracasei subsp. paracasei BCRC 14023 X X X X X
[323] Lactobacillus plantarum (CAU1054 OR CAU1055, OR CAU1064) OR Lactobacillus salivarius CAU1301 X X
[324] MegaSporeBiotic TM (MSB) probiotic capsules and MegaMucosa TM (MM) powder X X
[325] Bifidobacterium bifidum ATCC 29521 X X X X
[326] Lactobacillus acidophilus XY27 X X X X X X
[327] Minas Frescal probiotic cheese containing L. lactis X X
[328] Probiotic yeast
Saccharomyces boulardii (s. Boulardii)
X X X X X
[329] Lactobacillus acidophilus KDSL 1.0901,
Lactobacillus helveticus KDSL 1.8701, Lactobacillus plantarum
KDSL 1.0318, and mixed lactobacilli
X
[330] Lactobacillus gasseri 4M13 X X X X
[331] L. pentosus A14-6 and L. pentosus CMY46 X
[332] Lactobacillus acidophilus C4 X X X
[333] Exopolysaccharide Ropy Bifidobacterium pseudocatenulatum Bi-OTA128 X X X X
Others
[334] Insect (cockroach) Periplaneta americana X X
[335] MicroRNAs X X X X X X
[336] Insect (cockroach) Periplaneta americana X X X X X X
[337] Aspergillus awamori X X X X X
[338] Maggot extracts X
[339] Meroterpene algae 11-hydroxy-1′-O—methylamadione X X X
[340] Arthrospira (Spirulina) platensis X X
[341] hydroalcoholic extracts (HA) of cyanobacterium Spirulina platensis X
[342] Chinese propolis X X X X
[343] Saccharina japonica X X
[344] Aphanizomenon flos-aquae X X X X X
[345] Melanin from Sepia pharaonis ink X X X X
[346] Tuna bioactive peptides (TBP) X X
[347] Turtle peptide X X X
[348] Oxylipin-containing lyophilized biomass from a microalga X X X X
[349] Fermented Mekabu aqueous solution
by Lactobacillus plantarum Sanriku-SU7
X

Legend: CAT = catalase; COX2 = cyclooxigenase type 2; DNA = deoxyribonucleic acid; ERON = reactive oxygen and nitrogen species; GPx = glutathione peroxidase; GR = glutathione reductase; GSH = glutathione; GST = glutathione S-transferase; iNOS = inducible nitric oxide synthase; Iκ-Bα = nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; LP = lipid peroxidation; LPO = lipoxygenase; MDA = malondialdehyde; MPO = myeloperoxidase; NF-Κb = nuclear factor kappa-light-chain-enhancer of activated B cells; NO = nitric oxide; NOX = nicotinamide adenine dinucleotide phosphate-oxidase; Nrf2 = nuclear factor erythroid 2; PTN = protein; RONS = reactive oxygen and nitrogen species; SOD = superoxide dismutase; TAC = total antioxidant capacity.