FIG. 1.

(A) Schematic diagram showing the positions of the adenovirus early promoters. Open circles represent Tcf binding sites. (B and C) Annotated sequence of the E2/E3 and E1B promoter regions. Changes in Tcf viruses are shown below the wild-type sequence. Gaps are indicated by dots in the sequence (the Tcf insert is not the same length as the deleted wild-type sequence). The Tcf consensus sites are shown in bold. The E3 mutations do not change the encoded pVIII protein sequence (note that to meet this requirement the NF1 site mutation affects only a poorly conserved residue and may not influence NF1 binding).