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. 2024 Nov 11;12(11):2580. doi: 10.3390/biomedicines12112580

Figure 2.

Figure 2

Three-dimensional structure of the NCC dimer embedded in the apical cell membrane. This schematic representation highlights the functional domains of the transporter: (1) the extracellular domain (green); (2) the transmembrane domain (red); and (3) the cytosolic domain (blue). A close-up of one ion binding pocket, located within the transmembrane domain, shows three binding sites: one for Na+ (magenta); one for Cl− (cyan); and one for polythiazide, a thiazide diuretic (yellow). The representation is based on the structural prediction provided by the Orientations of Proteins in Membranes (OPM) database [22] of the NCC inward-facing conformation obtained by Fan et al. [20] (PDB ID: 8FHO). PyMOL (Schrödinger, LLC) was used to visualize the structure and generate the image. Figure created in BioRender.com [6].