Figure 4.

Progressive gait recovery after ventral root reimplantation with HFB, AT-MSC therapy, and DMF treatment. (A) Peroneal nerve Functional Index, indicating faster and more robust recovery following the combined therapy. Observe that the ventral root reimplantation alone shows partial recovery over time, which is statistically inferior to cell therapy alone or in combination with DMF. (B) Max contact (cm) indicating improvement in the pawprint ipsilateral to the lesion. (C) Maximum contact maximum intensity. (D) Step sequence. Note the significant recovery in the combined treatment group, which was sustained over time. (E) Base of support of front paws. (F) Base of support of hind paws. The results indicate a near-normal recovery in the ability to position the limbs during ambulation. (G) Representative images of the right (injured) and left (uninjured) paws obtained using the Catwalk System at different times during the experiment, showing the progressive motor recovery after injury and reimplantation of the roots. N = 5–6. * Indicates improvement over other groups. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, n.s.—non significant.