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. 2024 Nov 6;16(22):3752. doi: 10.3390/cancers16223752

Figure 4.

Figure 4

HDAC6 activity in BC cells. (A) NextA cytotoxic activity. BC cells were treated with NextA at concentrations ranging from 0.37 nM to 100 μM for 72 h. n = 3, mean ± SD. Cell viability was measured using MTS CellTiter96® Aqueous One Solution cell proliferation assay. (B) Whole HDAC classes I/II basal activity in both WT and HR BT474 and SKBR3 cell lines, * p < 0.05, ns: not significant; (C) WT and HR cells were treated with Nexturastat A at concentrations ranging between 0.008 μM and 12.5 μM. HDAC class I/II activity was measured using HDAC-GloTM class I/II assay.