Table 1.
This table contrasts the ranking positions obtained using the original version of SFpointer with the current E × S matrix against those generated with the four new enrichment methods using the updated EventPointer 3.14 pipeline and E × S. It also considers the database used, comparing POSTAR3 and its predecessor POSTAR2. The lowest ranking positions for each condition are highlighted in bold. NS stands for “not significant”. The numbers shown in red indicate the percentile ranking.
| RBP | POSTAR2 | POSTAR3 | |||||
|---|---|---|---|---|---|---|---|
|
SFPointer Original
(Fisher’s Exact Test) |
SFpointer Original
(Fisher’s Exact Test) |
SFpointer New (Fisher’s Exact Test) | SFpointer New (Poisson Binomial) | SFpointer New (GSEA) | SFpointer New (Wilcoxon Test) | ||
| PRJEB39343 | PTBP1 | - | 1/244|0.99 | 1| 0.99 | 1| 0.99 | 1| 0.99 | 2|0.99 |
| PRJEB39343 | MBNL1 | - | 81/244|0.67 | 9|0.96 | 4| 0.98 | 21|0.91 | 22|0.91 |
| GSE77702 | FUS | 11/195| 0.94 | 1/244|0.99 | 2|0.99 | 4|0.98 | 2|0.99 | 2|0.99 |
| GSE77702 | TAF15 | NS | 125/244|0.49 | 117| 0.52 | 152|0.37 | 164|0.32 | 177|0.27 |
| GSE77702 | TARDBP | 20/195|0.90 | 68/244|0.72 | 45|0.81 | 43|0.82 | 10| 0.96 | 30|0.88 |
| GSE136366 | TDP43 | - | 1/244|0.99 | 1| 0.99 | 1| 0.99 | 1| 0.99 | 1| 0.99 |
| GSE75491 | RBM47 | - | 7/244|0.97 | 8|0.97 | 3| 0.99 | 10|0.96 | 4|0.98 |