Figure 1.

Schematic diagram of computational screening to identify genes involved in the translation of structured mRNAs. An input list of 71 genes (Table S1) involved in translation and helicase activity were evaluated for their reported PPIs, GIs, and GE. Each match within the PPI dataset was given a score of 1, and each match within the GE and GI datasets were scored as 0.5. Among the high-scoring gene candidates, CAF20 and ECM32 were the top two genes with no previously published direct functional links to the translation of structured mRNAs. These two genes were subjected to follow-up investigation.