Figure 7.

Negative genetic interactions for CAF20 and ECM32. A collection of interactors falls in the categories of general translation and ribosome biogenesis for CAF20 (p = 3.83 × 10⁻⁷) and ECM32 (p = 4.52 × 10⁻⁷). DHH1, PAP2, RPL8B, and RPL11B are mutual hits shared between CAF20 and ECM32. Circles represent genes, while nGIs between CAF20 or ECM32 are represented by the circle’s perimeter coloration: blue for CAF20 and yellow for ECM32. Existing (previously published) interactions are differentiated by a black box outlining the circles. The strength of the interaction is reflected by the gradient, with darker coloration indicating a higher level of decreased fitness. A representative nGI is indicated in the inset by the red circle.