Figure 8.
Conditional negative genetic interactions for CAF20 and ECM32 under sub-inhibitory LiCl concentration of 3 mM. A collection of interactors falls in the categories of regulation of translation for CAF20 (p = 7.89 × 10−7) and ECM32 (p = 1.20 × 10−8); cytoplasmic translation for CAF20 (p = 1.41 × 10−7) and ECM32 (p = 5.67 × 10−7); ribosome biogenesis for CAF20 (p = 4.93 × 10−7). NST1, PET122, POP2, RPL22A, and SLF1 are mutual hits shared between CAF20 and ECM32. Circles represent genes, nGIs for CAF20 or ECM32 are represented by the circle’s perimeter coloration: blue for CAF20 and yellow for ECM32. Existing (previously published) interactions are differentiated by a black box outlining the circles. The strength of the interaction is reflected by the gradient, with darker coloration indicating decreased fitness. A representative nGI is indicated in the inset by the red circle.