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In situ analysis of small molecules interacting with membrane proteins with edge tracking approaches. (a) WGA binding to glycoprotein on SH-EP1 cells. (b) Acetylcholine binding to nicotinic acetylcholine receptors (ion channel) on SH-EP1-α4β2 cells. (c) AMD3100 binding to CXCR-4 receptors (GPCR) on A549 cells. (d) Insulin binding to insulin receptors (tyrosine kinase receptor) on Hep G2 cells, reprinted with permission from Ref. [39].
