Figure 3.

Enrichment analysis for identified pleiotropic genes. (A) The Wayne diagram showing POPS, MAGMA, and SMR pleiotropic gene screening. Significant types of pathways based on GO (B) and KEGG enrichment analyses (C). BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto encyclopedia of genes and genomes pathway. (D) Enrichment of differentially expressed genes among all identified pleiotropic genes across 54 GTEx tissues. The y-axis shows the p-values with a scale of −log₁₀. The bars in red represent significant enrichment with Bonferroni adjustment for multiple-hypothesis testing.