Table 2.
KEGG common pathways between ALD (alcohol-associated liver disease) and MASLD (metabolic dysfunction-associated liver disease) with at least 3 differentially methylated genes in alphabetical order.
| Pathways | Number of Genes with Changes in Methylation | |||
|---|---|---|---|---|
| Hypo ALD | Hyper ALD | Hypo MASLD | Hyper MASLD | |
| AMPK signaling pathway | 4 | 3 | ||
| Amoebiasis | 3 | 6 | ||
| Growth hormone synthesis, secretion and action | 4 | 3 | ||
| Human papillomavirus infection | 5 | 6 | ||
| Lipid and atherosclerosis | 3 | 4 | 3 | |
| Longevity-regulating pathway | 4 | 3 | ||
| Metabolic pathways | 3 | 34 | 6 | 9 |
| MicroRNAs in cancer | 3 | 3 | 4 | |
| Neutrophil extracellular trap formation | 3 | 3 | ||
| Pathogenic Escherichia coli infection | 3 | 3 | ||
| Pathways in cancer * | 7 | 6 | 11 | 7 |
| PI3K Akt signaling pathway | 3 | 3 | 7 | |
| Regulation of actin cytoskeleton | 5 | 3 | ||
| Thermogenesis | 5 | 3 | ||
| Tight junction | 3 | 4 | ||
| Transcriptional dysregulation in cancer | 3 | 3 | ||
* In pathways in cancer, the PPAR was differentially methylated in ALD and MASLD.