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. 2024 Nov 15;16(22):3836. doi: 10.3390/cancers16223836

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ATUX-3364 and ATUX-8385 decreased serine phosphorylation of MYCN. SK-N-AS (MYCN-non-amplified) and SK-N-BE(2) (MYCN-amplified) cells were treated with increasing concentrations of ATUX-3364 or ATUX-8385. Whole cell lysates were prepared, and immunoblotting completed for phosphorylated MYCN (P-S62) and total MYCN protein expression. Vinculin was assayed as a loading control. Serine 62 phosphorylation of MYCN was decreased with treatment with both drugs. Total MYCN protein expression was also decreased following treatment. The uncropped bolts are shown in Supplementary Materials.