Table 1.

Correlations of the thromboelastometry parameters vs. the DOAC concentrations or the VKA-INR, as measured for patients on chronic anticoagulation. Peak + trough DOAC concentrations were included in this analysis. CT-EXTEM or INTEM, coagulation time determined with extrinsic or intrinsic reagents. CFT-EXTEM or INTEM, clot formation time. MCF-EXTEM or INTEM, maximal clot firmness. VKA-INR, international normalized ratio for patients on VKAs. * Based on the linear regression line (DOAC concentration vs. the thromboelastometry CT).

Thromboelastometry Parameters vs. DOAC Concentrations			CT Value (95% CI) Corresponding to DOAC Concentrations of *
CT-EXTEM (seconds)	Rho	p value	400 ng/mL	20 ng/mL
DOACs (all)	0.725	<0.001	241 (233–249)	89 (81–97)
Apixaban	0.667	<0.001	150 (144–156)	78 (72–84)
Rivaroxaban	0.788	<0.001	236 (222–250)	99 (85–113)
Dabigatran	0.824	<0.001	224 (212–236)	91 (79–103)
Edoxaban	0.86	<0.001	341 (331–351)	105 (95–115)
CFT-EXTEM (seconds)
DOAC (all)	0.010	0.87
Apixaban	0.065	0.58
Rivaroxaban	−0.018	0.88
Dabigatran	0.047	0.73
Edoxaban	0.053	0.69
MCF-EXTEM (mm)
DOAC (all)	0.013	0.87
Apixaban	−0.044	0.71
Rivaroxaban	0.021	0.86
Dabigatran	0.213	0.12
Edoxaban	0.040	0.76
CT-INTEM (seconds)
DOAC (all)	0.49	<0.001
Apixaban	0.23	<0.05
Rivaroxaban	0.62	<0.001
Dabigatran	0.75	<0.001
Edoxaban	0.53	<0.001
CFT-INTEM (seconds)
DOAC (all)	0.066	0.29
Apixaban	0.23	<0.05
Rivaroxaban	0.12	0.35
Dabigatran	−0.04	0.57
Edoxaban	0.001	0.99
MCF-INTEM (mm)
DOAC (all)	0.08	0.21
Apixaban	−0.08	0.46
Rivaroxaban	0.08	0.51
Dabigatran	0.33	<0.05
Edoxaban	0.08	0.57
Thromboelastometry parameters vs. the VKA-INR
CT-EXTEM	0.58	<0.001
CFT-EXTEM	0.07	0.71
MCF-EXTEM	−0.33	0.06
CT-INTEM	0.45	<0.01
CFT-INTEM	0.32	0.07
MCF-INTEM	−0.16	0.38