Table 3.
Correlations of thrombin generation assay vs. thromboelastometry parameters for patients on DOACs or VKAs. DOAC peak + trough values were included in this analysis. CT-EXTEM, coagulation time determined with extrinsic reagents.
| Patients on DOACs | ||
|---|---|---|
| Lag time vs. CT-EXTEM | Rho | p value |
| DOAC (all) | 0.81 | <0.001 |
| Apixaban | 0.57 | <0.001 |
| Rivaroxaban | 0.87 | <0.001 |
| Edoxaban | 0.83 | <0.001 |
| Time-to-peak vs. CT-EXTEM | ||
| DOAC (all) | 0.82 | <0.001 |
| Apixaban | 0.55 | <0.001 |
| Rivaroxaban | 0.86 | <0.001 |
| Edoxaban | 0.83 | <0.001 |
| Peak-thrombin vs. CT-EXTEM | ||
| DOAC (all) | −0.67 | <0.001 |
| Apixaban | −0.37 | <0.001 |
| Rivaroxaban | −0.82 | <0.001 |
| Edoxaban | −0.65 | <0.001 |
| Endogenous thrombin potential vs. CT-EXTEM | ||
| DOAC (all) | −0.52 | <0.001 |
| Apixaban | −0.20 | 0.09 |
| Rivaroxaban | −0.72 | <0.001 |
| Edoxaban | −0.51 | <0.001 |
| Patients on VKAs | ||
| Lag time vs. CT-EXTEM | 0.72 | <0.001 |
| Time-to-peak vs. CT-EXTEM | 0.72 | <0.001 |
| Peak-thrombin vs. CT-EXTEM | −0.79 | <0.001 |
| Endogenous thrombin potential vs. CT-EXTEM | −0.75 | <0.001 |