Certainty of Evidence							Patients		Effect		Certainty
Nº of Studies	Study Design	Risk of Bias	Inconsistency	Indirect-ness Evidence	Imprecision	Others	[OMT]	[Placebo]	Relative (95% CI)	Absolute(95% CI)
Pain intensity (VAS or NPRS) in NP
2	RCTs	Serious a	Serious b	Serious c	Very serious d	None	31	24	-	SMD −0.42; (−1.24, 0.41)	⨁◯◯◯ Very low
Disability (NDI, ODI or RMDQ) in NP
2	RCTs	Serious a	Serious b	Serious c	Very serious d	None	31	24	-	SMD −0.24 (−1.15, 0.66)	⨁◯◯◯ Very low
Pain intensity (VAS or NPRS) in LBP
5	RCTs	Not serious	Serious b	Serious c	Not serious	None	588	546	-	SMD −0.10; (−0.38, 0.13)	⨁⨁◯◯ Low
Disability (NDI, ODI or RMDQ) in LBP
4	RCTs	Not serious	Not serious	Serious c	Not serious	None	578	536	-	SMD −0.07 (−0.22, 0.09)	⨁⨁⨁◯ Moderate
CI: confidence interval; SMD: standardized mean difference. Explanations: a More than 25% of the participants were from studies with poor or fair methodological quality, considering the following aspects: lack of allocation concealment, random allocation and/or sample size calculation, participant and personnel blinding, blinding of outcome assessors. b I2 level was higher than 50%. c Indirectness was downgraded because the interventions were heterogeneous. d Population included in each group < 30 participants. High: We are very confident that the true effect is close to the estimate of the effect. Moderate: We are moderately confidence in the effect estimate. The true effect is close to the estimate of the effect, but the result can be different. Low: Confidence in the effect estimate is limited, and the true effect can be substantially different from the estimate of the effect. Very Low: There is little confidence in the effect estimate, and the true effect is likely to be substantially different from the estimated effect.