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. 2024 Nov 20;16(22):3889. doi: 10.3390/cancers16223889

Table 6.

Results of analysis of prognostic factors for overall survival according to pStage.

Variables pStage I, II pStage III
Univariate Analysis Multivariate Analysis Univariate Analysis Multivariate Analysis
HR 95% CI p Value HR 95% CI p Value HR 95% CI p
Value
HR 95% CI p Value
Sex
Female 1 1 1 1
Male 1.731 1.419–2.111 <0.001 1.929 1.567–2.376 <0.001 1.236 0.998–1.532 0.053 1.252 1.006–1.558 0.044
Age (years)
<70 1 1 1 1
≥70 4.859 4.059–5.817 <0.001 4.159 3.444–5.024 <0.001 1.432 1.165–1.759 <0.001 1.206 0.963–1.509 0.103
Surgical procedure
Non-TG 1 1 1 1
TG 2.311 1.923–2.777 <0.001 1.722 1.415–2.095 <0.001 1.439 1.176–1.760 <0.001 1.376 1.119–1.692 0.002
Surgical approach
Laparoscopy 1 1 1 1
Open 2.298 1.937–2.726 <0.001 1.679 1.303–2.164 <0.001 1.446 0.876–2.388 0.149 1.963 1.117–3.452 0.019
Lymph node dissection
D1+ 1 1 1 1
D2 1.526 1.284–1.812 <0.001 0.797 0.621–1.023 0.075 0.590 0.404–0.863 0.006 0.480 0.314–0.734 <0.001
Histological type
Differentiated 1 1 1 1
Undifferentiated 0.594 0.499–0.707 <0.001 0.957 0.780–1.147 0.631 0.972 0.783–1.205 0.794 1.140 0.913–1.423 0.249
Score (Prealbumin cutoff: 15)
0 1 1 1 1
1 2.086 1.737–2.506 <0.001 2.027 1.664–2.469 <0.001 1.258 1.010–1.565 0.040 1.212 0.957–1.534 0.110
2 3.000 2.269–3.967 <0.001 2.535 1.879–3.420 <0.001 0.981 0.720–1.335 0.902 0.962 0.692–1.337 0.817
Postoperative complication
Absent 1 1 1 1
Overall complications 1.480 1.212–1.808 <0.001 1.250 1.006–1.553 0.044
Severe complications 1.535 1.128–2.091 0.006 1.194 0.873–1.632 0.267 1.444 1.061–1.966 0.020 1.269 0.923–1.746 0.143
Adjuvant chemotherapy
Absent 1 1 1 1
Present 1.848 1.454–2.349 <0.001 1.706 1.313–2.217 <0.001 0.520 0.423–0.640 <0.001 0.564 0.453–0.701 <0.001