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Consensus molecular subtypes of colorectal cancer.
| Subtype | Prevalence | Features |
|---|---|---|
| CMS1 (Microsatellite instability immune) | 14% | Hypermutated Microsatellite unstable Strong immune activation |
| CMS2 (Canonical) | 37% | Epithelial WNT and MYC signaling activation |
| CMS3 (Metabolic) | 13% | Epithelial Metabolic dysregulation |
| CMS4 (Mesenchymal) | 23% | TGF-β activation Stromal invasion Angiogenesis |
