The bioactivity of PSO (perilla seed oil) includes its effects in antimicrobial, antioxidant, anti-inflammatory, hypolipidemic, hypoglycemic, neuroprotective and immunomodulatory activities. Abbreviations: GSH, glutathione; SOD, superoxide dismutase; DPPH, 2,2-diphenyl-1-picrylhydrazyl; ROS, reactive oxygen species; MDA, malondialdehyde; LPO, lipid peroxidation; TNF-α, tumor necrosis factor-alpha; COX-2, cyclooxygenase-2; IL-1β, interleukin-1 beta; IL-6, interleukin-6; IL-10, interleukin-10; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; G6PD, glucose-6-phosphate dehydrogenase; BG, blood glucose; ChAT, choline acetyltransferase; TChE, total cholinesterase; IgG, immunoglobulin G; IgA, immunoglobulin A; IgE, immunoglobulin E.