Table 2.

The data on the repression of some genes using AAV vectors.

Serotype	Gene for Blocking	Model	Effect	Reference
AAV2	GABA(A)	KA, Kindling, rats	Modulation of colliculi inferiores convulsions	[245]
AAV2	NMDAR1	KA, rats	Significant decrease in sensitivity to focal seizures within 4 weeks. The design of the pTet promoter caused the opposite effect—a significant increase in sensitivity to seizures. It has been shown that in the brain, NMDA receptor excitation can cause GABA inhibition [21]; therefore, removing NMDA receptor excitation from these inhibitory interneurons can create a state of hyperexcitability.	[246]
AAV8	ADK	Transgenic mice with spontaneous epilepsy	Preventing convulsive activity	[247]
AAV9	lncRNA H19	KA, rats	The CA3 neurons were preserved	[250]
AAV10	Scn8a	KA, mice	Protection from spontaneous seizures; reduction of gliosis	[250]
AAV9	GluK2	Pilocarpine, mice	Reduction of chronic convulsive activity	[253]