TABLE 1.

Mean CSF leukocyte counts and CSF IL-1 and TNF-α concentrations in rabbits injected i.c. with PCW fragments, with and without fucoidin treatment^a

CSF index	PCW			PCW + fucoidin
	0 h	6 h	12 h	0 h	6 h	12 h
Leukocytes (106/liter)	1 ± 1.5	1,703 ± 295	2,048 ± 443	2 ± 2.6	3 ± 3.6b	148 ± 136c
Polynuclear	0	887 ± 223	635 ± 423	0	0b	68 ± 86c
Mononuclear	1 ± 1.5	808 ± 134	1,337 ± 122	2 ± 2.6	3 ± 3.6b	55 ± 50c
IL-1 (pg/liter)	<0.008	141 ± 32	97 ± 28	7.4 ± 5	20 ± 7b	31 ± 14
TNF-α (pg/liter)	<0.015	333 ± 182	260 ± 211	<0.015	184 ± 116	0c

^aPCW fragments were injected i.c. at 0 h. Fucoidin (10 mg/kg i.v.) was given 5 min prior to injection of PCW fragments and 2 and 4 h thereafter. The data are expressed as means ± standard errors of the mean. 

^bP < 0.05 versus PCW at 6 h. 

^cP < 0.05 versus PCW at 12 h.