TABLE 1.

Concordance and Discordance of NGS-MSI Versus IHC-MMR From a Cohort of 190,000 Tumors Across a Large Spectrum of Cancer Types

Cancer Type	Concordant	Discordant	Concordant	Discordant	% Concordance
	MMRd/MSI-H	MMRd/MSS	MMRp/MSS	MMRp/MSI-H
All	6,913	408	184,264	182	99.69
CRC	1,884	25	26,147	49	99.74
GE	480	22	9,338	9	99.69
SB	124	3	1,274	4	99.50
EC	2,740	48	11,299	42	99.36
Others	1,685	310	136,206	78	99.72

Abbreviations: CRC, colorectal carcinoma; EC, endometrial carcinoma; GE, gastroesophageal; MMRd, mismatch repair deficient; MMRp, mismatch repair proficient; MSI-H, microsatellite instability high; MSS, microsatellite stable; NGS-MSI, next-generation sequencing assessment of microsatellite instability; SB, small bowel.