Figure 2.

A network comprising experimental evidence of protein–protein interactions, considering genes in common between the GO and HPO repositories. The size of each node reflects the speed of information flow, with larger nodes indicating a faster flow. Pink and purple nodes represent genes with the highest levels of betweenness and closeness centrality, acting as critical control points for the flow and the speed at which information is relayed to other genes in the network. The green nodes—NOTCH1, TNNI3, and SMAD4—exhibit significant closeness centrality, playing key roles in mediating information flow within smaller groups of genes in the network.