Figure 1.

(A) An illustrative representation of a cross-section of the skin, indicating the layers (epidermis and dermis) that were resembled by the 3D hybrid hydrogel, depicted with information regarding its components, chemical formula, and structure. (B) Scheme of the co-culture strategy of the cell therapy product simulating the skin layers, with the deposition of keratinocytes in the membrane layer (resembling basement membrane of skin) and populating the porous layer with fibroblasts to obtain a cellular biomimetic dermal–epidermal skin substitute construct (not to scale).