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. 2024 Oct 30;15(11):1402. doi: 10.3390/genes15111402

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Diagram of the complex insertional PML::RARA fusion based on OGM and other genetic data in this study. Left: Ideograms of 2 normal chromosomes 15, a normal chromosome 17, and a derivative chromosome 17 with a complex, submicroscopic, and insertional PML::RARA fusion. Middle: The derivative chromosome 17 had a PML::RARA fusion due to an insertion of 15q24.1 including PML and other genes and a tandem duplication of 17q21.2 including RARA gene and other genes. Right: Breakpoints involved in the insertional PML::RARA fusion.