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. 2024 Nov 5;25(22):11876. doi: 10.3390/ijms252211876

Figure 3.

Figure 3

Expression levels of genes related to inflammation in liver of O-C, O-WD, and O-Rev male and female animals treated with vehicle or leptin during suckling and fed an SD or WD from weaning, at four months of age. Data are presented as the mean ± SEM (n = 8–12) and are expressed as a percentage of the value for the O-C male rats. Statistics: After data separation depending on post-weaning diet, three-way ANOVA was performed to analyze the effects of sex, maternal diet, and/or leptin treatment. In each sex, two-way ANOVA was performed to analyze the effects of leptin treatment and/or maternal diet. Single comparisons between leptin- and vehicle-treated rats of all experimental groups were carried out using the Mann–Whitney U test. Symbols: sex (S), maternal diet (MD), leptin treatment (L); Data that do not share a letter are significantly different, A ≠ B (p < 0.05, LSD post hoc, two- or three-way ANOVA); *, different from their vehicle-treated equal (p < 0.05, Mann–Whitney U test). Abbreviations: offspring of C-dams (O-C), offspring of WD-dams (O-WD), offspring of Rev-dams (O-Rev), vehicle (Veh), leptin (Lep).