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. 2024 Nov 18;25(22):12386. doi: 10.3390/ijms252212386

Table 3.

Comparison of tissue distribution between the D-isomer- and L-isomers of 211At-AAMT-O-Me-L in nude mice (PANC-1 tumor model).

1 Hour 3 Hour
D-Isomer L-Isomer D-Isomer L-Isomer
Brain 0.15 ± 0.01 0.46 ± 0.00 0.10 ± 0.03 0.29 ± 0.01
Thyroid 0.14 ± 0.04 0.20 ± 0.02 0.14 ± 0.06 0.23 ± 0.04
Salivary glands 0.30 ± 0.10 0.58 ± 0.05 0.33 ± 0.13 0.78 ± 0.18
Heart 0.53 ± 0.08 0.86 ± 0.04 0.37 ± 0.03 0.76 ± 0.07
Lung 2.24 ± 0.89 5.16 ± 0.11 1.27 ± 0.40 5.10 ± 0.42
Liver 3.09 ± 0.39 4.92 ± 0.24 2.60 ± 0.07 4.62 ± 0.20
Stomach 1.43 ± 0.94 1.32 ± 0.06 1.29 ± 0.77 1.31 ± 0.32
Small intestine 2.05 ± 0.81 3.40 ± 0.36 1.48 ± 0.37 2.50 ± 0.42
Colon 0.85 ± 0.49 1.14 ± 0.27 0.40 ± 0.25 0.68 ± 0.23
Kidney 1.40 ± 0.56 3.56 ± 0.09 1.54 ± 0.86 2.29 ± 0.07
Pancreas 0.61 ± 0.44 0.58 ± 0.01 0.48 ± 0.35 0.36 ± 0.10
Spleen 1.70 ± 0.74 4.34 ± 0.79 1.81 ± 1.19 3.97 ± 0.59
Testis 1.05 ± 0.77 0.55 ± 0.02 1.64 ± 1.26 0.55 ± 0.11
Blood 3.52 ± 1.89 7.85 ± 1.17 1.92 ± 1.16 10.38 ± 2.28
Bladder 1.76 ± 1.64 0.06 ± 0.00 1.04 ± 0.97 0.09 ± 0.01
Bone 0.30 ± 0.12 0.68 ± 1.27 0.26 ± 0.12 0.51 ± 1.35
Tumor 3.25 ± 1.39 7.83 ± 0.30 3.84 ± 2.10 10.29 ± 0.88
Cecum 2.35 ± 1.73 0.46 ± 0.05 1.32 ± 0.96 0.43 ± 0.16

All the data are presented as %ID/g (n = 3). All data are presented as means ± standard errors. All groups consisted of three mice.