Figure 3.

Analysis of Aβ1-40 plaques in the CA1, CA3, and DG regions of WT control, 6 M and 12 M 5XFAD Mice. (A) Representative sections of hippocampal organotypic slices stained with anti-Aβ1-40 antibodies and counterstained for hematoxylin/eosin. Arrows, asterisks, and arrowheads indicate positively immunostained cells. (B) Quantitative analysis of Aβ1-40-stained cells in the CA1, CA3, and DG hippocampal regions. The graph shows the density of Aβ1-40 staining in these hippocampal regions of 6 M and 12 M 5XFAD Mice relative to WT control. Data reported in all graph bars are expressed as mean ± SEM. ** p < 0.001 vs. WT control, * p < 0.05 vs. WT control. Scale bar: 30 μm.