Table 2.
General tumour characteristics of the study cohort.
| Case # | Diagnosis | International Neuroblastoma Risk Group (INGRSS) | MYCN Status | Pre-Treatment Risk Group | Multiple Body Compartments (Y/N) | Multi-Focal (Y/N) | Size of Tumour (AP Diam.) in mm | Size of Tumour (CC Diam.) in mm | Size of Tumour (TRV Diam.) in mm | Total Tumour Volume (cc) | Lobulated (Y/N) | Heterogenous (Y/N) | Calcification (Y/N) | Necrosis (Y/N) | Metastases (Y/N) | Metastases Type | Vascular Encasement (Y/N) | Vascular Encasement Vessels Involved | Adjacent Organ Infiltration (Y/N) | Type of Organ Infiltrated | Lymphadenopathy (Y/N) | Intraspinal Invasion (Y/N) | IDRF (Y/N) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GN | NA | N | N | 37 | 43 | 28 | 23.32 | N | Y | N | N | N | Y | Right vertebral artery | N | N | N | Y | ||||
| 2 | NB | MS | Non-amplified | Low risk | N | N | 42 | 65 | 39 | 55.75 | Y | Y | N | N | N | N | Y | Left sacral bone | N | Y | Y | ||
| 3 | NB | MS | Non-amplified | Low risk | Y | N | 35 | 69 | 49 | 61.96 | Y | Y | N | N | Y | Right cutaneous neck | Y | Right subclavian artery, proximal vertebral artery | Y | Right posterior 4th rib | Y | Y | Y |
| 4 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 65 | 57 | 53 | 102.11 | Y | Y | Y | N | N | N | N | N | N | N | |||
| 5 | GN | NA | N | N | 80 | 96 | 66 | 263.58 | Y | Y | N | N | N | N | N | N | N | N | |||||
| 6 | GNB | NA | N | N | 16 | 32 | 23 | 6.17 | N | N | N | N | N | N | N | N | Y | ||||||
| 7 | NB | M | Non-amplified | High risk | N | N | 23 | 31 | 26 | 9.71 | N | Y | N | N | Y | Bones | N | N | Y | N | N | ||
| 8 | NB | MS | Non-amplified | Low risk | N | N | 63 | 61 | 56 | 111.91 | Y | Y | N | N | Y | Liver, paraspinal, skull base, left orbital, left proximal femur | Y | Celiac, SMA | N | N | N | Y | |
| 9 | GN | NA | N | N | 36 | 60 | 40 | 44.93 | Y | Y | N | N | N | N | N | N | N | N | |||||
| 10 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 13 | 18 | 8 | 0.98 | Y | N | N | N | N | N | N | N | N | N | |||
| 11 | GNB | NA | N | N | 34 | 64 | 26 | 29.42 | Y | Y | N | N | N | Y | Thoracic aorta | N | N | N | Y | ||||
| 12 | NB | L2 | Non-amplified | Intermediate risk | N | N | 74 | 115 | 97 | 432.22 | Y | Y | Y | N | Y | Left paraaortic lymph nodes | N | N | Y | Y | Y | ||
| 13 | NB | L2 | Non-amplified | Intermediate risk | N | N | 47 | 52 | 50 | 63.98 | Y | Y | Y | N | N | N | Y | Left paravertebral muscles | N | Y | Y | ||
| 14 | GN | NA | N | N | 30 | 29 | 15 | 6.83 | N | N | N | N | N | N | N | Y | N | N | |||||
| 15 | GN | NA | N | N | 86 | 80 | 47 | 168.15 | Y | Y | Y | N | N | Y | IVC | N | N | N | Y | ||||
| 16 | GNB | NA | N | N | 33 | 30 | 30 | 15.44 | Y | Y | Y | N | N | N | N | N | N | N | |||||
| 17 | NB | L2 | Non-amplified | Intermediate risk | N | N | 56 | 93 | 92 | 249.15 | Y | Y | Y | N | N | Y | Aorta | N | N | Y | Y | ||
| 18 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 38 | 39 | 25 | 19.27 | Y | Y | N | N | N | N | N | N | N | N | |||
| 19 | NB | L2 | Non-amplified | Intermediate risk | N | N | 83 | 127 | 95 | 520.73 | Y | Y | N | Y | N | Y | Left common iliac artery, left renal artery and vein | Y | Left psoas muscle | N | N | Y | |
| 20 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 23 | 43 | 24 | 12.34 | Y | N | N | N | N | N | N | N | N | N | |||
| 21 | NB | MS | Non-amplified | Low risk | N | N | 43 | 57 | 58 | 73.92 | Y | Y | N | N | Y | Liver | Y | Aorta, IVC, celiac, SMA, left renal artery and vein | N | N | N | Y | |
| 22 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 19 | 24 | 13 | 3.08 | Y | Y | N | N | N | N | N | Y | N | N | |||
| 23 | GNB | NA | N | N | 16 | 16 | 8 | 1.06 | N | N | N | N | N | N | N | N | N | N | |||||
| 24 | NB | M | Unknown | High risk | N | N | 104 | 170 | 104 | 962.75 | Y | Y | N | Y | Y | Liver, pelvic bones, sacrum, spine, left iliac bone | Y | SMA, left renal vessels | Y | Left kidney | N | N | Y |
| 25 | NB | M | Unknown | High risk | N | N | 44 | 49 | 28 | 31.39 | Y | Y | Y | N | Y | Liver, bones (right prox femur, left iliac bone, right sacrum, T12, L3 vertebral bodies) | N | N | Y | N | N | ||
| 26 | NB | L2 | Non-amplified | Low risk | N | N | 106 | 121 | 76 | 510.39 | Y | Y | N | Y | N | N | N | N | Y | Y | |||
| 27 | GNB | NA | N | N | 63 | 100 | 61 | 199.84 | Y | Y | N | N | N | N | N | N | N | N | |||||
| 28 | NB | M | Non-amplified | High risk | N | N | 74 | 90 | 60 | 207.79 | Y | Y | N | Y | Y | Vertebral bodies, pelvic bones | Y | Left renal artery and vein | N | N | N | N | |
| 29 | GN | NA | N | N | 11 | 22 | 7 | 0.88 | N | N | N | N | N | N | N | N | N | N | |||||
| 30 | NB | L2 | Non-amplified | Intermediate risk | N | N | 28 | 42 | 50 | 30.58 | Y | Y | N | N | N | Y | Descending aorta | Y | Left paraspinal muscles | N | N | Y | |
| 31 | NB | L2 | Non-amplified | Low risk | N | N | 22 | 38 | 24 | 10.43 | Y | Y | N | N | N | Y | Right internal jugular vein | N | N | N | Y | ||
| 32 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 34 | 17 | 24 | 7.26 | Y | N | N | N | N | Y | Bilateral common iliac arteries | N | N | N | Y | ||
| 33 | GNB | NA | N | N | 79 | 107 | 105 | 464.73 | Y | Y | N | N | N | Y | Right renal artery and vein | N | N | N | Y | ||||
| 34 | GN | NA | N | N | 60 | 89 | 63 | 176.15 | Y | Y | Y | Y | N | N | N | N | N | N | |||||
| 35 | GN | N | N | 24 | 30 | 30 | 11.31 | N | N | N | N | N | N | N | N | N | N | ||||||
| 36 | GN | NA | N | N | 32 | 60 | 50 | 50.27 | N | Y | N | N | N | N | N | N | N | N | |||||
| 37 | NB | L1 | Non-amplified | Low risk (surgery only) | N | N | 37 | 18 | 55 | 19.18 | N | N | N | N | N | N | N | N | N | N | |||
| 38 | NB | L2 | Non-amplified | Intermediate risk | N | N | 26 | 41 | 42 | 23.44 | Y | Y | Y | N | N | N | Y | Right paraspinal muscles | N | Y | Y | ||
| 39 | NB | L2 | Non-amplified | Intermediate risk | N | N | 37 | 48 | 30 | 27.9 | Y | Y | N | N | N | N | Y | Right paraspinal muscles L2–3 | N | Y | Y | ||
| 40 | GN | NA | N | N | 47 | 86 | 63 | 133.33 | Y | Y | N | N | N | N | N | N | N | N |
Abbreviations: Y, yes; N, no; NA, not applicable; NB, neuroblastoma; GNB, ganglioneuroblastoma; GN, ganglioneuroma; IDRF, image-defined risk factor.