Table 6.
Diagnostic accuracy measures for quantitative MRI features and age at diagnosis based on neuroblastic tumours included in the retrospective study.
| Feature | Sensitivity (95% CI) |
Specificity (95% CI) |
Positive LR (95% CI) | Accuracy (95% CI) |
DOR and Log DOR |
|---|---|---|---|---|---|
| ADC cut-off small ROI, 1.06 × 10−3 mm2/s |
0.83 (0.68, 0.98) |
0.75 (0.54, 0.98) |
3.33 (1.40, 7.94) |
0.80 (0.64, 0.91) |
DOR = 15.14 Log DOR = 2.71 |
| ADC cut-off large ROI, 1.22 × 10−3 mm2/s |
0.79 (0.63, 0.94) |
0.83 (0.62, 1.00) |
2.44 (1.28, 4.65) |
0.80 (0.64, 0.91%) |
DOR = 18.33 Log DOR = 2.91 |
| Tumour volume cut-off, 56 cc | 0.50 (0.29, 0.71) |
0.63 (0.35, 0.85) |
1.33 (0.63, 2.83) |
0.55 (0.38, 0.71) |
DOR = 1.67 Log DOR = 0.51 |
| Age at diagnosis cut-off, 48 months | 0.96 (0.79, 1.00) |
0.81 (0.54, 0.96) |
5.11 (1.84, 14.22) |
0.90 (0.76, 0.97) |
DOR = 99.66 Log DOR = 4.60 |
Abbreviations: DOR = diagnostic odds ratio; ADC = apparent diffusion coefficient; LR = likelihood ratio; Log = logarithmic (natural). Legend: All cut-off values were determined by Youden’s Index, and accuracy measures were calculated to 95% confidence intervals, p < 0.05.